The Longevity Reality Radar

Partial epigenetic reprogramming (ER-100)

Partial epigenetic reprogramming (Life Biosciences ER-100). Aging itself. Reviewed Jul 2026.

A first-in-human safety trial in the eye has started, but every efficacy result so far comes from animals.

Stage
Phase 1, in the eye
Rung: In human trials. Phase 1 to 3. Being tested in people now. Most will not make it.
Evidence grade
D
animal data only
Animal or lab only, single pilot, or case reports. How grades work.

What it is

Gene therapy that resets epigenetic marks to make old cells behave younger without erasing cell identity. First-in-human study cleared by the FDA in Jan 2026, starting in the eye (glaucoma / NAION).

The evidence

FDA IND cleared; Phase 1 safety/tolerability underway. Animal data shows restored vision and tissue rejuvenation.

What you can do today

Outside a registered clinical trial, this is not something you can responsibly get. If it is relevant to you, the route is a trial: ask your specialist, or search a trial registry such as ClinicalTrials.gov for studies you may qualify for.

Sources

No primary paper or registry record is linked for this entry yet. The evidence summary names the studies it relies on.

Change history

No ladder moves or corrections logged for this entry yet. Changes are dated on the change log.

Related

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